MS4A2

Across TCGA patient cohorts, MS4A2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A2-associated genes across cancer lineages are PDCD4, TIGAR, and EGFR_pY1068. Each is linked with MS4A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A2-to-partner and partner-to-MS4A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MS4A2-low versus MS4A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A2→partner) and Y-score (partner→MS4A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.860	-2.990	.001	.036	3	2
UCEC	TIGAR →	+0.228	+3.026	.009	.019	3	1
UCEC	EGFR_pY1068 →	-0.331	-3.000	.022	.036	2	1
UCEC	FASN →	+0.559	+3.000	.014	.037	1	1
UCEC	MEK1 →	+0.512	+3.000	.015	.037	1	1
UCEC	Akt →	-0.322	-3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PDCD4 by MS4A2 expression — UCEC

Explore this box plot interactively →