Across TCGA pan-cancer cohorts, MS4A18 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MS4A18’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where MS4A18 RNA is repressed in tumor relative to normal tissue. In most cancer types MS4A18 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

LUSC, PRAD, and LUAD are the cancer types where MS4A18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MS4A18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.109	.001	5	view →
PRAD	All	All	+0.313	<.001	2	view →
LUAD	Female	All	+0.150	.037	1	view →
HNSC	Female	All	+0.019	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: MS4A18 RNA expression & survival · all MS4A18 data types