MS4A15

Across TCGA patient cohorts, MS4A15 mutation is significantly associated with the RNA expression of many other genes, with 766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A15-associated genes across cancer lineages are RNU6-597P, RNU6-13P, and RNA5SP536. Each is linked with MS4A15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A15-to-partner and partner-to-MS4A15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-597P grouped by MS4A15-low versus MS4A15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A15→partner) and Y-score (partner→MS4A15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-597P →	+0.558	+2.640	<.001	.002	3	2
LUAD	RNU6-13P →	+0.459	+3.453	<.001	.009	3	2
UCEC	RNA5SP536 →	+0.228	+3.985	<.001	.001	3	2
LUAD	OR6R1P →	+0.034	+4.631	.001	<.001	3	2
LUAD	FTLP13 →	+0.097	+4.912	<.001	.003	3	2
LUAD	MIR4536-2 →	+0.416	+4.444	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 766 associations by consensus.

RNU6-597P by MS4A15 expression — UCEC

Explore this box plot interactively →