MS4A15

Across TCGA cell cohorts, MS4A15 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MS4A15-associated genes across cancer lineages are OR4F4 and DEFA3. Each is linked with MS4A15 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A15-to-partner and partner-to-MS4A15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by MS4A15-low versus MS4A15-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A15→partner) and Y-score (partner→MS4A15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.025	+4.273	<.001	.006	3	1
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR4F4 by MS4A15 expression — LARGE_INTESTINE

Explore this box plot interactively →