MS4A14

Across TCGA patient cohorts, MS4A14 mutation is significantly associated with the RNA expression of many other genes, with 4,758 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A14-associated genes across cancer lineages are SCN4B, MIR5092, and GGA3. Each is linked with MS4A14 in more than 3 cancer types. Because this analysis shows association rather than direction, both MS4A14-to-partner and partner-to-MS4A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCN4B grouped by MS4A14-low versus MS4A14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A14→partner) and Y-score (partner→MS4A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SCN4B →	-0.350	-1.473	.004	.007	3	4
GBM	MIR5092 →	+0.708	+5.244	<.001	.001	3	3
UCEC	GGA3 →	+0.310	+2.436	.005	.001	3	3
UCEC	IFI6 →	-1.572	-1.947	<.001	<.001	3	3
UCEC	GINS4 →	+0.606	+1.958	.001	<.001	3	3
UCEC	DPH7 →	+0.421	+1.990	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,758 associations by consensus.

SCN4B by MS4A14 expression — UCEC

Explore this box plot interactively →