MS4A14

Across TCGA patient cohorts, MS4A14 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A14-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and ACVRL1. Each is linked with MS4A14 in more than 2 cancer types. Because this analysis shows association rather than direction, both MS4A14-to-partner and partner-to-MS4A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MS4A14-low versus MS4A14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A14→partner) and Y-score (partner→MS4A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.262	+1.584	.043	.034	3	3
UCEC	JNK_pT183_Y185 →	-0.164	-1.906	.003	.015	3	3
LUAD	ACVRL1 →	-0.126	-2.584	.044	.011	3	2
UCEC	eIF4G →	+0.311	+3.700	.002	.001	3	2
UCEC	mTOR_pS2448 →	-0.110	-1.893	.024	.014	3	2
UCEC	p27_pT198 →	+0.118	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

FASN by MS4A14 expression — UCEC

Explore this box plot interactively →