MS4A14

Across TCGA cell cohorts, MS4A14 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MS4A14-associated genes across cancer lineages are HPGDS, DGKK, and MYH7. Each is linked with MS4A14 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A14-to-partner and partner-to-MS4A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HPGDS grouped by MS4A14-low versus MS4A14-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A14→partner) and Y-score (partner→MS4A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HPGDS →	+0.097	+4.392	<.001	.003	3	1
OESOPHAGUS	DGKK →	+0.049	+4.017	<.001	.007	3	1
OESOPHAGUS	MYH7 →	+0.034	+4.017	.001	.007	3	1
BREAST	CCL23 →	+0.044	+5.169	<.001	.005	3	1
SKIN	MYL7 →	+0.339	+3.345	<.001	.007	3	1
SKIN	IL26 →	+0.070	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

HPGDS by MS4A14 expression — OESOPHAGUS

Explore this box plot interactively →