MS4A10

Across TCGA pan-cancer cohorts, MS4A10 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MS4A10 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MS4A10 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated MS4A10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SCLC, and READ are the cancer types where MS4A10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.436	.013	26	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	12	view →
READ	DFS	Median	II,III,IV	0.112	0.800	.002	6	view →
LUSC	OS	Median	All	0.081	0.818	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MS4A10–UCEC (DFS)

Open the UCEC breakdown →