MS4A10

Across TCGA cell cohorts, MS4A10 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MS4A10-associated genes across cancer lineages are SENP3, TAFA1, and THNSL1. Each is linked with MS4A10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A10-to-partner and partner-to-MS4A10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP3 grouped by MS4A10-low versus MS4A10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A10→partner) and Y-score (partner→MS4A10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SENP3 →	+0.562	+3.067	.003	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.183	+3.009	.007	.001	3	1
LARGE_INTESTINE	THNSL1 →	+0.983	+3.087	<.001	.006	3	1
LARGE_INTESTINE	CENPVL3 →	+0.177	+2.920	<.001	.001	3	1
LARGE_INTESTINE	SH3GL2 →	+1.049	+3.474	.006	.003	2	1
LARGE_INTESTINE	SLC25A19 →	+0.747	+3.064	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

SENP3 by MS4A10 expression — LARGE_INTESTINE

Explore this box plot interactively →