MS4A1

Across TCGA pan-cancer cohorts, MS4A1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MS4A1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MS4A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MS4A1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where MS4A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.791	0.289	<.001	18	view →
HNSC	DFS	Tertile	All	0.907	1.000	.017	9	view →
PDAC	DFS	Tertile	III,IV	1.000	0.220	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MS4A1–LUAD (DFS)

Open the LUAD breakdown →