MS4A1

Across TCGA pan-cancer cohorts, MS4A1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MS4A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MS4A1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MS4A1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where MS4A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MS4A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.289	<.001	9	view →
LSCC	All	All	+0.573	<.001	7	view →
LUAD	Male	All	+0.538	<.001	4	view →
PDAC	Female	All	+1.226	.003	2	view →
HNSC	Male	III,IV	−0.733	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MS4A1–COAD

Open the COAD breakdown →