MS4A1

Across TCGA patient cohorts, MS4A1 mutation is significantly associated with the RNA expression of many other genes, with 1,445 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A1-associated genes across cancer lineages are TRMU, RNU6-214P, and UHRF1. Each is linked with MS4A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MS4A1-to-partner and partner-to-MS4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by MS4A1-low versus MS4A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A1→partner) and Y-score (partner→MS4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TRMU →	+0.521	+3.497	.001	.002	3	3
LUSC	RNU6-214P →	+0.368	+2.823	.001	.006	3	3
UCEC	UHRF1 →	+0.816	+3.180	.001	<.001	3	2
UCEC	H3C7 →	+0.804	+2.831	<.001	.001	3	2
SKCM	MYO19 →	+0.508	+3.732	.002	<.001	3	2
SKCM	MFN1P1 →	+0.018	+2.052	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,445 associations by consensus.

TRMU by MS4A1 expression — SKCM

Explore this box plot interactively →