MS4A1

Across TCGA patient cohorts, MS4A1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A1-associated genes across cancer lineages are Notch1, Rab25, and Caspase-8. Each is linked with MS4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A1-to-partner and partner-to-MS4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MS4A1-low versus MS4A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A1→partner) and Y-score (partner→MS4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.190	+2.179	.001	.034	3	2
UCEC	Rab25 →	-0.298	-1.700	.034	.044	3	2
UCEC	Caspase-8 →	-0.244	-3.143	.022	.018	3	2
UCEC	EGFR_pY1068 →	-0.289	-2.584	.006	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.175	+2.235	.045	.006	3	1
UCEC	p21 →	+0.186	+3.459	.022	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Notch1 by MS4A1 expression — UCEC

Explore this box plot interactively →