MRTO4

Across TCGA cell cohorts, MRTO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,715 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRTO4-associated GO terms across cancer lineages are DNA replication initiation, RNA 5'-end processing, and rRNA 5'-end processing. Each is linked with MRTO4 in more than 18 cancer types. Because this analysis shows association rather than direction, both MRTO4-to-partner and partner-to-MRTO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by MRTO4-low versus MRTO4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRTO4→partner) and Y-score (partner→MRTO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication initiation →	+0.181	+0.758	<.001	<.001	3	19
LUNG_NSCLC_LUSC	RNA 5'-end processing →	+0.083	+0.898	.002	.005	3	18
BLOOD_Myeloma	rRNA 5'-end processing →	+0.152	+1.303	<.001	<.001	3	18
SOFT_TISSUE	Positive regulation of cell cycle phase transition →	+0.099	+0.859	<.001	<.001	3	18
LIVER	Spindle elongation →	+0.226	+1.013	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Mitotic spindle midzone assembly →	+0.250	+0.968	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,715 associations by consensus.

DNA replication initiation by MRTO4 expression — BONE

Explore this box plot interactively →