Across TCGA pan-cancer cohorts, MRTFB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRTFB data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MRTFB mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRTFB expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and COAD are the cancer types where MRTFB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.879	0.331	<.001	22	view →
CCRCC	OS	Quartile	III,IV	0.873	0.437	.014	11	view →
COAD	DFS	Median	II,III,IV	1.000	0.926	.044	6	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.917	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MRTFB tumor-vs-normal RNA expression · all MRTFB data types