Across TCGA patient cohorts, MRTFB mutation is significantly associated with the RNA expression of many other genes, with 4,700 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MRTFB-associated genes across cancer lineages are MTCO3P46, UHRF1, and MIR1268B. Each is linked with MRTFB in more than 2 cancer types. Because this analysis shows association rather than direction, both MRTFB-to-partner and partner-to-MRTFB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRTFB→partner) and Y-score (partner→MRTFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	MTCO3P46 →	+0.308	+5.029	.005	.002	3	3
UCEC	UHRF1 →	+0.625	+1.470	.002	.008	3	3
STAD	MIR1268B →	+1.011	+3.722	.006	.006	3	3
STAD	HMGB1P50 →	+0.280	+3.666	.004	.007	3	3
LUAD	ACD →	+0.541	+3.494	.002	.002	3	3
LUAD	OGFOD2 →	+0.417	+3.248	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,700 associations by consensus.

Exploration

MRTFB survival (RNA) · tumor vs normal (RNA) · all MRTFB data types