Across TCGA cell cohorts, MRTFB mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRTFB-associated genes across cancer lineages are ACTRT2, IZUMO3, and LYZL4. Each is linked with MRTFB in more than 1 cancer types. Because this analysis shows association rather than direction, both MRTFB-to-partner and partner-to-MRTFB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRTFB→partner) and Y-score (partner→MRTFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ACTRT2 →	+0.013	+4.196	<.001	.006	3	2
BLOOD_Leukemia	IZUMO3 →	+0.043	+4.384	<.001	.006	3	2
OESOPHAGUS	LYZL4 →	+0.631	+4.017	.004	.007	3	1
OESOPHAGUS	C3orf85 →	+0.895	+4.857	.003	<.001	3	1
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1
BREAST	CPLX4 →	+0.029	+3.887	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

MRTFB survival (RNA) · tumor vs normal (RNA) · all MRTFB data types