Across TCGA cell cohorts, MRTFA mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRTFA-associated genes across cancer lineages are H2BC1, H2AC1, and IFNL2. Each is linked with MRTFA in more than 1 cancer types. Because this analysis shows association rather than direction, both MRTFA-to-partner and partner-to-MRTFA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRTFA→partner) and Y-score (partner→MRTFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
SOFT_TISSUE	IFNL2 →	+0.075	+4.635	<.001	.003	3	1
SOFT_TISSUE	DPRX →	+0.049	+4.369	<.001	.008	3	1
LARGE_INTESTINE	FGF23 →	+0.463	+3.584	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

MRTFA survival (RNA) · tumor vs normal (RNA) · all MRTFA data types