MRS2

Across TCGA patient cohorts, MRS2 mutation is significantly associated with the RNA expression of many other genes, with 2,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRS2-associated genes across cancer lineages are TRBV23OR9-2, ELMO2P1, and RNU6-73P. Each is linked with MRS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRS2-to-partner and partner-to-MRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV23OR9-2 grouped by MRS2-low versus MRS2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRS2→partner) and Y-score (partner→MRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRBV23OR9-2 →	+0.262	+6.016	<.001	.002	3	2
UCEC	ELMO2P1 →	+0.159	+1.847	<.001	.001	3	2
CESC	RNU6-73P →	+0.930	+5.103	<.001	.008	3	2
CESC	GRAMD4P1 →	+0.056	+6.837	<.001	<.001	3	2
BRCA	GOLGA6C →	+0.050	+5.096	<.001	.008	3	2
BRCA	RNU6-776P →	+0.612	+7.471	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,570 associations by consensus.

TRBV23OR9-2 by MRS2 expression — BRCA

Explore this box plot interactively →