MRS2

Across TCGA patient cohorts, MRS2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRS2-associated genes across cancer lineages are Notch1, FoxM1, and mTOR_pS2448. Each is linked with MRS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRS2-to-partner and partner-to-MRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MRS2-low versus MRS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRS2→partner) and Y-score (partner→MRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.212	+1.584	<.001	.036	3	3
UCEC	FoxM1 →	+0.288	+2.000	.004	.010	3	2
UCEC	mTOR_pS2448 →	-0.190	-3.787	.001	<.001	3	2
UCEC	PCNA →	+0.287	+3.459	<.001	.005	3	2
UCEC	TAZ →	-0.114	-1.584	.040	.036	3	2
UCEC	ATM →	-0.365	-1.584	.040	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Notch1 by MRS2 expression — UCEC

Explore this box plot interactively →