MRS2

Across TCGA cell cohorts, MRS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,506 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MRS2-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, Negative regulation of nucleobase-containing compound transport, and Nuclear pore complex assembly. Each is linked with MRS2 in more than 14 cancer types. Because this analysis shows association rather than direction, both MRS2-to-partner and partner-to-MRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by MRS2-low versus MRS2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRS2→partner) and Y-score (partner→MRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of RNA export from nucleus →	+0.157	+0.843	.001	.001	3	15
BONE	Negative regulation of nucleobase-containing compound transport →	+0.143	+0.634	<.001	.003	3	14
PANCREAS	Nuclear pore complex assembly →	+0.138	+0.859	<.001	<.001	3	12
PANCREAS	Recombinational repair →	+0.075	+0.923	.001	<.001	3	11
BONE	DNA strand elongation →	+0.159	+0.994	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair →	+0.061	+0.621	.006	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,506 associations by consensus.

Negative regulation of RNA export from nucleus by MRS2 expression — STOMACH

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