MRS2

Across TCGA cell cohorts, MRS2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRS2-associated genes across cancer lineages are MMP26, CHST8, and STATH. Each is linked with MRS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRS2-to-partner and partner-to-MRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by MRS2-low versus MRS2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRS2→partner) and Y-score (partner→MRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MMP26 →	+0.505	+4.285	<.001	.007	3	2
BLOOD_Leukemia	CHST8 →	+0.313	+4.263	<.001	.002	3	1
BLOOD_Leukemia	STATH →	+0.413	+4.133	<.001	.003	3	1
BLOOD_Leukemia	SLCO1C1 →	+0.087	+3.705	<.001	.007	3	1
BLOOD_Leukemia	SPRR2G →	+0.115	+3.551	.002	.009	3	1
BLOOD_Leukemia	OR4K2 →	+0.025	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MMP26 by MRS2 expression — STOMACH

Explore this box plot interactively →