MRPS5

Across TCGA pan-cancer cohorts, MRPS5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MRPS5 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRPS5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and UCEC are the cancer types where MRPS5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.672	.004	14	view →
LUAD	DFS	Quartile	III,IV	0.875	0.255	.013	7	view →
UCEC	DFS	Median	II,III,IV	0.553	0.868	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MRPS5–LSCC (OS)

Open the LSCC breakdown →