MRPS5

Across TCGA patient cohorts, MRPS5 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS5-associated genes across cancer lineages are 14-3-3_beta, IRS1, and JNK_pT183_Y185. Each is linked with MRPS5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS5-to-partner and partner-to-MRPS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MRPS5-low versus MRPS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS5→partner) and Y-score (partner→MRPS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.095	-3.432	.022	.005	3	1
UCEC	IRS1 →	+0.224	+1.807	.009	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.191	-2.459	.005	.019	3	1
UCEC	Notch1 →	+0.220	+4.087	<.001	<.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.449	-3.169	.015	.019	3	1
UCEC	p62 Lck ligand →	+0.358	+3.179	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by MRPS5 expression — UCEC

Explore this box plot interactively →