MRPS35

Across TCGA pan-cancer cohorts, MRPS35 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MRPS35 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS35 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRPS35 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where MRPS35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	1.000	0.662	.005	19	view →
UCEC	DFS	Median	II,III,IV	0.553	0.868	.024	4	view →
LUAD	DFS	Quartile	II,III,IV	0.917	0.613	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MRPS35–LSCC (OS)

Open the LSCC breakdown →