MRPS35

Across TCGA patient cohorts, MRPS35 mutation is significantly associated with the RNA expression of many other genes, with 1,861 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS35-associated genes across cancer lineages are MTND2P22, MIR6803, and MIR517C. Each is linked with MRPS35 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS35-to-partner and partner-to-MRPS35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND2P22 grouped by MRPS35-low versus MRPS35-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS35→partner) and Y-score (partner→MRPS35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MTND2P22 →	+0.039	+7.914	<.001	<.001	3	2
UCEC	MIR6803 →	+0.244	+5.362	<.001	<.001	3	2
HNSC	MIR517C →	+0.385	+6.339	<.001	.001	3	2
HNSC	MRPL49P1 →	+0.078	+5.368	<.001	.005	3	2
UCEC	RFKP1 →	+0.134	+3.104	<.001	<.001	3	2
BRCA	RNU6-381P →	+0.331	+8.471	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,861 associations by consensus.

MTND2P22 by MRPS35 expression — LIHC

Explore this box plot interactively →