MRPS31

Across TCGA pan-cancer cohorts, MRPS31 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MRPS31 data layer compared with 18 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MRPS31 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRPS31 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and COAD are the cancer types where MRPS31 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.804	0.543	.001	30	view →
LSCC	DFS	Tertile	II,III,IV	0.949	0.493	.001	27	view →
COAD	DFS	Tertile	All	1.000	0.878	.042	18	view →
PDAC	DFS	Tertile	II,III,IV	0.607	0.312	.010	10	view →
GBM	OS	Quartile	All	0.674	0.437	.019	3	view →
LUAD	DFS	Quartile	All	0.978	0.903	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MRPS31–HNSC (OS)

Open the HNSC breakdown →