MRPS30

Across TCGA patient cohorts, MRPS30 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS30-associated genes across cancer lineages are Caspase-7-cleavedD198, Heregulin, and JNK_pT183_Y185. Each is linked with MRPS30 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPS30-to-partner and partner-to-MRPS30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MRPS30-low versus MRPS30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS30→partner) and Y-score (partner→MRPS30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.667	+2.019	.005	.017	3	3
UCEC	Heregulin →	-0.112	-2.986	.024	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.145	-2.000	.032	.030	3	1
UCEC	p62 Lck ligand →	+0.281	+1.906	.031	.016	3	1
UCEC	Annexin-1 →	+0.452	+2.604	.032	.005	3	1
UCEC	Syk →	+0.305	+1.920	.043	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caspase-7-cleavedD198 by MRPS30 expression — UCEC

Explore this box plot interactively →