MRPS26

Across TCGA pan-cancer cohorts, MRPS26 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRPS26 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS26 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS26 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and PDAC are the cancer types where MRPS26 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.945	0.464	.002	18	view →
GBM	OS	Median	All	0.633	0.424	.002	14	view →
PDAC	OS	Median	IV	0.491	0.836	.024	12	view →
CCRCC	DFS	Median	III,IV	0.403	0.723	.011	6	view →
UCEC	DFS	Median	II,III,IV	0.509	0.867	.033	4	view →
HNSC	OS	Quartile	All	0.762	0.899	.015	4	view →
LUAD	DFS	Tertile	All	0.486	0.698	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRPS26–LSCC (DFS)

Open the LSCC breakdown →