Across TCGA pan-cancer cohorts, MRPS21P3 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MRPS21P3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MRPS21P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPS21P3 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.

HNSC, UCEC, and ESCA are the cancer types where MRPS21P3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS21P3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.128	.027	5	view →
UCEC	All	All	+0.232	.008	2	view →
ESCA	Male	All	−0.362	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MRPS21P3 RNA expression & survival · all MRPS21P3 data types