Across TCGA pan-cancer cohorts, MRPS21P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MRPS21P1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MRPS21P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPS21P1 is over-expressed in tumor.
KIRP and LIHC are the cancer types where MRPS21P1 tumor–normal differential expression is most reproducible.