MRPS21

Across TCGA pan-cancer cohorts, MRPS21 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS21 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS21 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS21 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where MRPS21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.599	.005	15	view →
PDAC	OS	Median	II,III,IV	0.439	0.288	.019	11	view →
LUAD	DFS	Tertile	All	0.415	0.892	.007	7	view →
UCEC	DFS	Median	II,III,IV	0.509	0.867	.037	4	view →
HNSC	DFS	Median	II,III,IV	0.977	0.898	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS21–LSCC (DFS)

Open the LSCC breakdown →