MRPS21

Across TCGA patient cohorts, MRPS21 mutation is significantly associated with the RNA expression of many other genes, with 1,147 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS21-associated genes across cancer lineages are RPS29P27, MBD3L3, and CRYBB2P1. Each is linked with MRPS21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS21-to-partner and partner-to-MRPS21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P27 grouped by MRPS21-low versus MRPS21-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS21→partner) and Y-score (partner→MRPS21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RPS29P27 →	+0.234	+7.640	<.001	.009	3	2
COAD	MBD3L3 →	+0.129	+7.741	<.001	.009	3	1
UCEC	CRYBB2P1 →	+0.548	+2.721	.002	.003	3	1
UCEC	MFNG →	+0.634	+2.721	.003	.003	3	1
UCEC	SRRD →	+0.565	+3.499	.001	.002	3	1
UCEC	TFIP11 →	+0.569	+3.329	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,147 associations by consensus.

RPS29P27 by MRPS21 expression — BLCA

Explore this box plot interactively →