MRPS21

Across TCGA patient cohorts, MRPS21 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS21-associated genes across cancer lineages are C-Raf, 14-3-3_beta, and EGFR_pY1068. Each is linked with MRPS21 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS21-to-partner and partner-to-MRPS21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MRPS21-low versus MRPS21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS21→partner) and Y-score (partner→MRPS21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.277	+2.584	<.001	.011	3	2
UCEC	14-3-3_beta →	-0.113	-2.973	.015	.035	3	1
UCEC	EGFR_pY1068 →	-0.397	-3.700	<.001	.001	3	1
UCEC	ERK2 →	+0.225	+2.999	.012	.035	3	1
UCEC	INPP4B →	-0.350	-2.999	.020	.035	3	1
UCEC	ACVRL1 →	-0.183	-2.302	.003	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

C-Raf by MRPS21 expression — UCEC

Explore this box plot interactively →