MRPS2

Across TCGA pan-cancer cohorts, MRPS2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS2 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where MRPS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.890	0.507	.001	28	view →
LUAD	DFS	Tertile	II,III,IV	0.991	0.599	.003	17	view →
PDAC	OS	Quartile	All	0.314	0.640	.003	13	view →
GBM	OS	Tertile	All	0.629	0.434	.030	2	view →
CCRCC	OS	Median	All	0.712	0.913	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS2–LSCC (DFS)

Open the LSCC breakdown →