MRPS2

Across TCGA cell cohorts, MRPS2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRPS2-associated genes across cancer lineages are ETNPPL, ELOA3DP, and OR2G6. Each is linked with MRPS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS2-to-partner and partner-to-MRPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ETNPPL grouped by MRPS2-low versus MRPS2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS2→partner) and Y-score (partner→MRPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETNPPL →	+0.222	+4.021	<.001	.001	3	1
LARGE_INTESTINE	ELOA3DP →	+0.026	+3.103	<.001	.004	3	1
SKIN	OR2G6 →	+0.019	+5.415	<.001	.004	3	1
LARGE_INTESTINE	C16orf96 →	+0.516	+3.520	.003	.005	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ETNPPL by MRPS2 expression — LARGE_INTESTINE

Explore this box plot interactively →