Across TCGA pan-cancer cohorts, MRPS18B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS18B data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPS18B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS18B expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and LUAD are the cancer types where MRPS18B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.862	.043	12	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.695	.021	5	view →
LUAD	DFS	Quartile	III,IV	0.875	0.435	.026	4	view →
PDAC	OS	Quartile	III,IV	0.500	1.000	.040	2	view →
CCRCC	DFS	Median	III,IV	0.427	0.678	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MRPS18B tumor-vs-normal RNA expression · all MRPS18B data types