MRPS18A

Across TCGA pan-cancer cohorts, MRPS18A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS18A data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MRPS18A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPS18A expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where MRPS18A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.128	0.952	.003	26	view →
PDAC	OS	Median	III,IV	1.000	0.537	.008	16	view →
HNSC	DFS	Median	III,IV	0.753	0.454	<.001	15	view →
LUAD	DFS	Median	All	0.478	0.924	.002	8	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.870	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS18A–CCRCC (DFS)

Open the CCRCC breakdown →