MRPS17

Across TCGA patient cohorts, MRPS17 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS17-associated genes across cancer lineages are SNORD116-23, IGFL3, and RNU6-11P. Each is linked with MRPS17 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS17-to-partner and partner-to-MRPS17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-23 grouped by MRPS17-low versus MRPS17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS17→partner) and Y-score (partner→MRPS17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD116-23 →	+0.618	+2.432	.004	.009	3	2
UCEC	IGFL3 →	+0.726	+2.715	<.001	.004	3	1
UCEC	RNU6-11P →	+0.386	+2.626	.002	.006	3	1
UCEC	RNY4P3 →	+0.352	+2.833	.003	.006	3	1
UCEC	RNA5SP248 →	+0.595	+3.557	<.001	<.001	3	1
UCEC	RNU6-136P →	+0.388	+2.603	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

SNORD116-23 by MRPS17 expression — UCEC

Explore this box plot interactively →