MRPS12

Across TCGA pan-cancer cohorts, MRPS12 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS12 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MRPS12 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS12 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and OV show a favorable association.

CCRCC, OV, and PDAC are the cancer types where MRPS12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.825	0.640	.011	11	view →
OV	DFS	Tertile	All	1.000	0.490	.032	8	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	8	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.813	.017	2	view →
LUAD	OS	Quartile	All	0.428	0.861	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS12–CCRCC (DFS)

Open the CCRCC breakdown →