MRPS11

Across TCGA pan-cancer cohorts, MRPS11 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MRPS11 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS11 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where MRPS11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.501	.002	12	view →
CCRCC	DFS	Median	All	1.000	0.600	.008	10	view →
HNSC	OS	Median	II,III,IV	0.814	0.616	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MRPS11–LSCC (DFS)

Open the LSCC breakdown →