MRPS11

Across TCGA patient cohorts, MRPS11 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS11-associated genes across cancer lineages are 14-3-3_beta, Rab11, and C-Raf. Each is linked with MRPS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS11-to-partner and partner-to-MRPS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MRPS11-low versus MRPS11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS11→partner) and Y-score (partner→MRPS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.110	-3.571	.023	.002	3	1
UCEC	Rab11 →	-0.138	-2.459	.048	.020	3	1
UCEC	C-Raf →	+0.171	+2.459	.013	.019	3	1
UCEC	Dvl3 →	+0.175	+3.000	.049	.036	3	1
UCEC	VHL →	-0.806	-3.169	.014	.019	2	1
UCEC	Gab2 →	+0.366	+2.459	.034	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

14-3-3_beta by MRPS11 expression — UCEC

Explore this box plot interactively →