MRPS11

Across TCGA cell cohorts, MRPS11 mutation is significantly associated with the drug of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRPS11-associated genes across cancer lineages are AZD7969, LCL161, and GSK2801. Each is linked with MRPS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS11-to-partner and partner-to-MRPS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD7969 grouped by MRPS11-low versus MRPS11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS11→partner) and Y-score (partner→MRPS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD7969 →	+0.458	+2.649	.045	.046	3	1
LARGE_INTESTINE	LCL161 →	+0.459	+2.672	.004	.039	3	1
LARGE_INTESTINE	GSK2801 →	+0.380	+2.678	.016	.037	3	1
LARGE_INTESTINE	50869 →	+0.469	+2.649	.026	.046	3	1
LARGE_INTESTINE	IWP-2 →	+0.353	+2.893	.007	.034	2	1
LARGE_INTESTINE	SGC-CBP30 →	+0.396	+2.649	.004	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

AZD7969 by MRPS11 expression — LARGE_INTESTINE

Explore this box plot interactively →