MRPL58

Across TCGA pan-cancer cohorts, MRPL58 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MRPL58 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MRPL58 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MRPL58 expression acts as an unfavorable survival marker.

KIRC and COAD are the cancer types where MRPL58 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.172	0.805	.001	24	view →
COAD	OS	Median	All	0.181	0.806	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MRPL58–KIRC (OS)

Open the KIRC breakdown →