MRPL58

Across TCGA pan-cancer cohorts, MRPL58 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MRPL58 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MRPL58 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL58 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where MRPL58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.746	0.934	.012	12	view →
CCRCC	DFS	Tertile	II,III,IV	0.497	0.809	.011	8	view →
LSCC	DFS	Tertile	II,III,IV	0.903	0.595	.027	6	view →
GBM	OS	Tertile	All	0.611	0.398	.009	5	view →
PDAC	DFS	Tertile	IV	0.777	0.217	.024	3	view →
LUAD	DFS	Median	III,IV	0.709	0.348	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MRPL58–HNSC (DFS)

Open the HNSC breakdown →