MRPL58

Across TCGA cell cohorts, MRPL58 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,867 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRPL58-associated GO terms across cancer lineages are U4 snRNA 3'-end processing, Semaphorin-plexin signaling pathway, and Pseudouridine synthesis. Each is linked with MRPL58 in more than 8 cancer types. Because this analysis shows association rather than direction, both MRPL58-to-partner and partner-to-MRPL58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, U4 snRNA 3'-end processing grouped by MRPL58-low versus MRPL58-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL58→partner) and Y-score (partner→MRPL58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	U4 snRNA 3'-end processing →	+0.102	+0.612	<.001	<.001	3	9
PANCREAS	Semaphorin-plexin signaling pathway →	-0.105	-0.528	.001	.002	3	9
LUNG_SCLC	Pseudouridine synthesis →	+0.055	+0.414	.004	.002	3	9
STOMACH	Positive regulation of axonogenesis →	-0.084	-0.747	.003	.002	3	8
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.110	+0.692	<.001	<.001	3	8
LUNG_SCLC	Regulation of mitochondrial translation →	+0.126	+0.569	.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,867 associations by consensus.

U4 snRNA 3'-end processing by MRPL58 expression — BLOOD_Leukemia

Explore this box plot interactively →