MRPL57

Across TCGA pan-cancer cohorts, MRPL57 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MRPL57 data layer compared with 20 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher MRPL57 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MRPL57 expression acts as an unfavorable survival marker.

ESCA, ACC, and UCEC are the cancer types where MRPL57 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.226	0.686	.013	12	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MRPL57–ESCA (OS)

Open the ESCA breakdown →