MRPL57

Across TCGA pan-cancer cohorts, MRPL57 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MRPL57 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MRPL57 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MRPL57 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

CCRCC, COAD, and LSCC are the cancer types where MRPL57 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.118	0.789	.002	22	view →
COAD	DFS	Median	All	1.000	0.923	.043	12	view →
LSCC	OS	Median	II,III,IV	1.000	0.895	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MRPL57–CCRCC (OS)

Open the CCRCC breakdown →