MRPL57

Across TCGA patient cohorts, MRPL57 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL57-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK_pT183_Y185, and JNK2. Each is linked with MRPL57 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL57-to-partner and partner-to-MRPL57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by MRPL57-low versus MRPL57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL57→partner) and Y-score (partner→MRPL57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.194	-2.990	.007	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.247	-2.986	.011	.037	3	1
UCEC	JNK2 →	+0.419	+2.817	<.001	.036	3	1
UCEC	STAT3_pY705 →	-0.615	-2.999	<.001	.035	3	1
UCEC	Tuberin →	+0.500	+3.009	.001	.019	3	1
UCEC	ATM →	-0.544	-3.000	.038	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

FOXO3a_pS318_S321 by MRPL57 expression — UCEC

Explore this box plot interactively →