MRPL54

Across TCGA pan-cancer cohorts, MRPL54 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPL54 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL54 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL54 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where MRPL54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.911	.012	48	view →
HNSC	DFS	Tertile	IV	0.597	0.933	.002	29	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.514	.022	3	view →
GBM	OS	Quartile	All	0.567	0.286	.014	2	view →
PDAC	OS	Median	II,III,IV	0.290	0.420	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPL54–COAD (DFS)

Open the COAD breakdown →